BioResponse Supplements DIM 150
What is BioResponse DIM®?

Patented BioResponse DIM® is a microencapsulated, absorption-enhanced formulation of DIM. With regular use, BioResponse DIM® helps balance our hormone metabolism.

This unique nutrient delivery method for DIM guarantees the absorption of DIM.

•DIM stands for 3,3’-Diindolylmethane, the natural indole found only in cruciferous vegetables.

•DIM occurs within the cruciferous vegetable plant after crushing or chewing. Plant enzymes produce DIM from precursors called glucosinolates.

•DIM promotes beneficial estrogen metabolism in both women and men. This estrogen metabolism is more favorable because it increases conversion of estrogen to 2-hydroxy and 2-methoxy metabolites. DIM is not a plant estrogen.

Prominent researchers have documented that this balance of estrogen metabolites is an important factor in maintaining breast, uterine, cervical and prostate health. Women and men also use BioResponse DIM as an integral part of successful weight management programs.

In its pure, crystalline state, DIM is inadequately absorbed by the human body. Microencapsulated BioResponse DIM is the only absorbable (bioavailable) formulation of pure DIM.

BioResponse DIM is the only DIM with proven absorption and activity demonstrated in independently performed clinical studies. BioResponse's patented formulation contains microencapsulated complexes of diindolylmethane for guaranteed and sustained gastrointestinal absorption.

How BioResponse DIM® Works

BioResponse-DIM acts to overcome the extreme insolubility of DIM and makes DIM absorbable from the human digestive tract. The absorption-enhancing formulation is a patented, nutrient delivery system necessary for adequate absorption of pure DIM. Once absorbed, DIM from BioResponse DIM acts to promote and support a favorable metabolism of estrogen and related hormones.

BioResponse DIM® contains pure DIM, microencapsulated in particles complexed with a vitamin E derivative and phospholipids to allow absorption from our intestinal track. The patented formulation process for making BioResponse-DIM creates microparticles of DIM, emulsifies the DIM with Vitamin E and phospholipids, and captures these complexes through a drying process in larger particles of pure food starch. This results in a sustained-release, dry powder which re-dissolves easily after oral consumption.

When included as a dietary ingredient, BioResponse DIM use supports metabolism and augments our dietary intake of cruciferous vegetables. A daily intake of 3-5 servings of vegetables, especially cruciferous vegetables, is recommended by the USDA "Dietary Guidelines for Americans". BioResponse DIM provides a source of cruciferous indole which is shelf-stable following mixture, encapsulation or tableting with other dietary supplement ingredients. Regular use of BioResponse DIM serves to augment or replace deficient daily intake of cruciferous vegetables, contributing to health promotion.

How is BioResponse DIM unique?

•BioResponse DIM promotes a more favorable metabolism of estrogen.

•Unlike I3C (Indole-3-carbinol), DIM released from BioResponse DIM requires no action by stomach acid to be active as a support for metabolism.

•BioResponse DIM promotes the production of 2 hydroxyestrone and 2-methoxyestrone, keymetabolites in men and women.

•BioResponse DIM provides proven bioavailability of highly insoluble active DIM through action of its patented dosage form and delivery system.

The Advantages of BioResponse DIM®

For centuries, people have known that cruciferous vegetables - broccoli, brussels sprouts, cabbage, and cauliflower - have value as medicinal plants. But only recently has modern science pinpointed the specific activity of individual cruciferous phytonutrients, especially diindolylmethane (DIM). To be beneficial, pure DIM needs to be made bioavailable. This hurdle was cleared in 1998 when BioResponse Nutrients developed its unique and patented nutrient delivery system - the only patented microencapsulated technology that guarantees the absorption of DIM.

Patented BioResponse DIM® is the only microencapsulated formulation of pure DIM. BioResponse DIM® is also the only DIM with proven absorption and benefits demonstrated in independently performed clinical studies. This patented technology is currently the only nutrient delivery method that assures predictable absorption and sustained delivery of diindolylmethane.

BioResponse DIM® offers substantially higher absorption values than generic DIM.

The issue of absorption and bioavailability of DIM is a real issue as DIM is highly insoluble. Michael A. Zeligs, M.D., the founder and CEO of BioResponse Nutrients LLC, is the originator of the only bioavailable microencapsulated DIM. In 2000, BioResponse was awarded a patent for enhanced absorption of DIM, the only formulation that has received a US patent.

The microencapsulated formulation of DIM (BioResponse DIM®) contains a minimum of 25% of diindolylmethane. Our 150 mg capsules contain a minimum of 37.5 mg of diindolylmethane. Generic DIM, although it may contain a higher percentage of diindolylmethane, has been shown in studies to be very poorly absorbed.

Please refer to the graph above, which shows the absorption results of a comparison of absorbable BioResponse DIM versus generic DIM. Note that this study compares 300 mg of BioResponse DIM, providing 75 mg diindolylmethane, to a generic DIM capsule, providing 100 mg diindolylmethane.

The BioResponse DIM showed substantially higher absorption values than the generic DIM, even though 25% less diindolylmethane was delivered with this dose of BioResponse DIM. Microencapsulated BioResponse DIM displays much higher absorption, while the generic DIM shows little absorption at all.

Recently, a number of knock-off manufacturers are attempting to position products offering a higher milligram amount of DIM in formulations without addressing the need for an absorption-enhancing microencapsulated formulation. Simply increasing the milligrams of DIM does not result in any predictable absorption. Our formulation is the only DIM formulation shown to shift the estrogen metabolite ratio in clinical studies.

Bioresponse DIM Complex is the only formulation with proven absorption. No studies have shown that black pepper works as an additive to generic DIM to improve absorption. BR-DIM's patented, micro-encapsulated diindolylmethane is the only DIM proven to achieve significantly higher blood-levels.

All published clinical studies have only used the BioResponse patented DIM formulation. BioResponse DIM is the only DIM clinically tested in humans and is also the only DIM in clinical trials sponsored by the National Cancer Institute.